Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human PD1 protein (Active) (ab214141)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human PD1 protein (Active)
    See all PD1 proteins and peptides

  • Biological activity

    Measured by its binding ability in a functional ELISA.

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    Q15116

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQ

    • Amino acids

      25 to 167

    • Additional sequence information

      (NP_005009.2). Expected molecular weight ~16 kD, observed molecular weight 30 kD in SDS-PAGE due to glycosylation of the protein.

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab214141 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

        Functional Studies

      • Form

        Lyophilized

      • Additional notes

        Endotoxin levels determined by LAL test.

         

      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

        Constituent: PBS

        Lyophilized from 0.2µm-filtered solution.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5 mg/ml. Add 1X PBS to the desired protein concentration. PBS containing at least 0.1% BSA should be used for further dilutions.

      General Info

      • Alternative names

        • CD279
        • CD279 antigen
        • hPD 1
        • hPD l
        • hPD-1
        • hSLE1
        • PD 1
        • PD-1
        • PD1
        • PDCD 1
        • PDCD1
        • PDCD1_HUMAN
        • Programmed cell death 1
        • Programmed cell death 1 protein
        • Programmed cell death protein 1
        • Protein PD 1
        • Protein PD-1
        • SLEB2
        • Systemic lupus erythematosus susceptibility 2
        see all

      • Function

        Possible cell death inducer, in association with other factors.

      • Involvement in disease

        Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

      • Sequence similarities

        Contains 1 Ig-like V-type (immunoglobulin-like) domain.

      • Developmental stage

        Induced at programmed cell death.

      • Cellular localization

        Membrane.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab214141? Please let us know so that we can cite the reference in this datasheet.

    ab214141 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • CD279
      • CD279 antigen
      • hPD 1
      • hPD l
      • hPD-1
      • hSLE1
      • PD 1
      • PD-1
      • PD1
      • PDCD 1
      • PDCD1
      • PDCD1_HUMAN
      • Programmed cell death 1
      • Programmed cell death 1 protein
      • Programmed cell death protein 1
      • Protein PD 1
      • Protein PD-1
      • SLEB2
      • Systemic lupus erythematosus susceptibility 2
      see all

    • Function

      Possible cell death inducer, in association with other factors.

    • Involvement in disease

      Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Developmental stage

      Induced at programmed cell death.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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