Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant human PD1 protein (Fc Chimera) (ab198774)

Key features and details

Expression system: HEK 293 cells
Purity: > 90% SDS-PAGE
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Product name

Recombinant human PD1 protein (Fc Chimera)
See all PD1 proteins and peptides
Biological activity

PD-1-PD-L1 binding activity.
Purity

> 90 % SDS-PAGE.
Expression system

HEK 293 cells
Accession

Q15116
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Human
- Sequence
  
  LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSN QTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCG AISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQIEGRMDP KSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVS HEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGK EYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTC LVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRW QQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- Predicted molecular weight
  
  43 kDa including tags
- Amino acids
  
  25 to 167
- Additional sequence information
  
  Fused to the Fc region of Human IgG1 at the C terminus.

Alternative names
- CD279
- CD279 antigen
- hPD 1
- hPD l
- hPD-1
- hSLE1
- PD 1
- PD-1
- PD1
- PDCD 1
- PDCD1
- PDCD1_HUMAN
- Programmed cell death 1
- Programmed cell death 1 protein
- Programmed cell death protein 1
- Protein PD 1
- Protein PD-1
- SLEB2
- Systemic lupus erythematosus susceptibility 2
see all
Function

Possible cell death inducer, in association with other factors.
Involvement in disease

Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Developmental stage

Induced at programmed cell death.
Cellular localization

Membrane.
Target information above from: UniProt accession Q15116 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant human PD1 protein (Fc Chimera) (ab198774)

4-20% SDS-PAGE analysis of ab198774 with Coomassie staining.
Lane 1: 2 µg ab198774
Lane 2: Protein marker
ab198774 runs at a higher MW by SDS-PAGE due to glycosylation.
Functional Studies - Recombinant human PD1 protein (Fc Chimera) (ab198774)

Activity assay using ab198774.

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