Recombinant rabbit PD1 protein (Fc Chimera Active) (ab221021)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: SDS-PAGE, ELISA
Preparation and Storage
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Alternative names
- CD279
- CD279 antigen
- hPD 1
see all -
Function
Possible cell death inducer, in association with other factors. -
Involvement in disease
Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Developmental stage
Induced at programmed cell death. -
Cellular localization
Membrane. - Information by UniProt
Images
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ELISA - Recombinant Rabbit PD1 protein (Fc Chimera) (ab221021)
Immobilized Mouse PD-L1, His Tag at 10 μg/mL (100 μL/well) can bind ab221021 with a linear range of 3-50 ng/mL.
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SDS-PAGE - Recombinant Rabbit PD1 protein (Fc Chimera) (ab221021)SDS-PAGE analysis of DTT-reduced ab221021 stained overnight with Coomassie Blue. DTT-reduced protein migrates as 55-66 kDa.
