Recombinant mouse PD1 protein (Fc Chimera) (ab221326)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: SDS-PAGE
Preparation and Storage
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Alternative names
- CD279
- CD279 antigen
- hPD 1
see all -
Function
Possible cell death inducer, in association with other factors. -
Involvement in disease
Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Developmental stage
Induced at programmed cell death. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant mouse PD1 protein (Fc Chimera) (ab221326)Mouse PD-1, mouse IgG2a Fc tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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Functional Studies - Recombinant mouse PD1 protein (Fc Chimera) (ab221326)Immobilized Mouse PD-L2, Fc Tag at 5 µg/mL (100 µL/well) can bind Mouse PD-1, mouse IgG2a Fc tag with a linear range of 0.078-0.625 µg/mL. -
Functional Studies - Recombinant mouse PD1 protein (Fc Chimera) (ab221326)Immobilized Mouse PD-L1, Fc Tag at 5 µg/mL (100 µL/well) can bind Mouse PD-1, mouse IgG2a Fc tag with a linear range of 0.078-0.313 µg/mL. -
SDS-PAGE - Recombinant Mouse PD1 protein (Fc Chimera) (ab221326)SDS-PAGE analysis of reduced (lane 1) and non-reduced (lane 2) ab221326 staining overnight with Coomassie Blue.
The protein migrates as 55-66 kDa under reducing conditions and 100-130 kDa under non-reducing conditions on SDS-PAGE gel.
