Compound 401, DNA-dependent protein kinase and mTOR inhibitor (ab120968)
Key features and details
- Selective, reversible DNA-dependent protein kinase and mTOR inhibitor
- CAS Number: 168425-64-7
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Compound 401, DNA-dependent protein kinase and mTOR inhibitor -
Description
Selective, reversible DNA-dependent protein kinase and mTOR inhibitor -
Biological description
Selective, reversible DNA-dependent protein kinase and mTOR inhibitor (IC50 values are 0.28 and 5.3 μM respectively). No affinity for PI3K, ATM and ATR (IC50 values are >100 μM). Able to induce apoptosis in vitro. Cell-permeable.
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Purity
> 99% -
CAS Number
168425-64-7 -
Chemical structure
Properties
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Chemical name
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one -
Molecular weight
281.31 -
Molecular formula
C16H15N3O2 -
PubChem identifier
10039361 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C2C=C(N=C1c3ccccc3C=CN12)N4CCOCC4 -
Source
Synthetic
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Research areas
