AS-604850, ATP-competitive PI3Kgamma inhibitor (ab120935)
Key features and details
- Selective, ATP-competitive PI3Kγ inhibitor
- CAS Number: 648449-76-7
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AS-604850, ATP-competitive PI3Kgamma inhibitor -
Description
Selective, ATP-competitive PI3Kγ inhibitor -
Biological description
Selective, ATP-competitive PI3Kγ inhibitor (IC50 values are 0.25 (PI3Kγ), >20 (PI3Kδ and PI3Kβ), and 4.5 µM (PI3Kα)). Pharmacologically active in vivo. -
Purity
> 98% -
CAS Number
648449-76-7 -
Chemical structure
Properties
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Chemical name
5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione -
Molecular weight
285.22 -
Molecular formula
C11H5F2NO4S -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C1NC(=O)/C(=Cc2ccc3OC(F)(F)Oc3c2)S1 -
Source
Synthetic
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Research areas