Aloisine A, CDK inhibitor (ab143750)
Key features and details
- Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDKs.
- CAS Number: 496864-16-5
- DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Aloisine A, CDK inhibitor -
Description
Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDKs. -
Alternative names
- 7-n-butyl-6-(4'-hydroxyphenyl)-5H-pyrrolo[2,3b]pyrazine
- 7-n-butyl-6-(4'-hydroxyphenyl)-5H-pyrrolo[2,3b]pyrazine
- 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
- RP107
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Biological description
Cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 150nM), CDK2/cyclin A (IC50 = 120nM), CDK2/cyclin E (IC50 = 400nM), CDK5/p25 (IC50 = 200nM), CDK5/p35 (IC50 = 160nM) and GSK-3α (IC50 = 500nM). Also inhibits GSK-3β (IC50 = 650nM) and c-Jun N-terminal kinase (JNK) (IC50 = ~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100µM). Blocks cell cycle progression in both G1 and G2 phase.
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CAS Number
496864-16-5 -
Chemical structure
Properties
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Chemical name
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol -
Molecular weight
267.33 -
Molecular formula
C16H17N3O -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
