SAHA (Vorinostat), HDAC inhibitor (ab144480)
Key features and details
- Potent non-selective HDAC inhibitor
- CAS Number: 149647-78-9
- Purity: > 98%
- Soluble in ethanol to 50 mM (with warming) and in DMSO to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SAHA (Vorinostat), HDAC inhibitor -
Description
Potent non-selective HDAC inhibitor -
Alternative names
- Vorinostat
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Biological description
Potent non-selective HDAC inhibitor (IC50 values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC50 = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.
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Purity
> 98% -
CAS Number
149647-78-9 -
Chemical structure
Properties
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Chemical name
N1-Hydroxy-N8-phenyloctanediamide -
Molecular weight
264.32 -
Molecular formula
C14H20N2O3 -
PubChem identifier
5311 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM (with warming) and in DMSO to 100mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO -
Source
Synthetic
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Research areas