Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human TIM 4 protein (Fc Chimera Active) (ab214961)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human TIM 4 protein (Fc Chimera Active)
    See all TIM 4 proteins and peptides

  • Biological activity

    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

  • Purity

    > 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    Q96H15-1

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      ETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGM RVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVK INVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTT PDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPIL TAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDS VSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQL

    • Predicted molecular weight

      80 kDa including tags

    • Amino acids

      25 to 315

    • Additional sequence information

      Fused to the N-terminus of the Fc region of mouse IgG2a.

    • Specifications

    Our Abpromise guarantee covers the use of ab214961 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute with 100 µL sterile water. Add 1X PBS to the desired protein concentration. Working aliquots are stable for up to 3 months when stored at -20°C.

    General Info

    • Alternative names

      • SMUCKLER
      • Spleen, mucin-containing, knockout of lymphotoxin protein
      • T cell immunoglobulin and mucin domain containing protein 4
      • T-cell immunoglobulin and mucin domain containing 4
      • T-cell immunoglobulin and mucin domain containing molecule
      • T-cell immunoglobulin and mucin domain-containing protein 4
      • T-cell immunoglobulin and mucin domains-containing protein 4
      • T-cell membrane protein 4
      • TIM-4
      • Tim4
      • TIMD 4
      • TIMD-4
      • Timd4
      • TIMD4_HUMAN
      see all

    • Function

      Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

    • Sequence similarities

      Belongs to the immunoglobulin superfamily. TIM family.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Domain

      Recognizes phosphatidyl serine via its immunoglobulin domain.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab214961? Please let us know so that we can cite the reference in this datasheet.

ab214961 has not yet been referenced specifically in any publications.

Preparation and Storage

  • SMUCKLER
  • Spleen, mucin-containing, knockout of lymphotoxin protein
  • T cell immunoglobulin and mucin domain containing protein 4

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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