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Recombinant mouse TIM 4 protein (Fc Chimera Active) (ab214993)

Key features and details

  • Expression system: CHO cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant mouse TIM 4 protein (Fc Chimera Active)
    See all TIM 4 proteins and peptides

  • Biological activity

    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated Human T cells.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    Q6U7R4

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      AASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRT DGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFN DVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLP TTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNH SQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKS HQINSRQT

    • Predicted molecular weight

      28 kDa

    • Amino acids

      22 to 279

    • Additional sequence information

      Extracellular domain fused to the N-terminus of the Fc region of Human IgG1 (NP_848874.3).

    • Specifications

    Our Abpromise guarantee covers the use of ab214993 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      Lyophilized from 0.2µm filtered solution.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

    General Info

    • Alternative names

      • SMUCKLER
      • Spleen, mucin-containing, knockout of lymphotoxin protein
      • T cell immunoglobulin and mucin domain containing protein 4
      • T-cell immunoglobulin and mucin domain containing 4
      • T-cell immunoglobulin and mucin domain containing molecule
      • T-cell immunoglobulin and mucin domain-containing protein 4
      • T-cell immunoglobulin and mucin domains-containing protein 4
      • T-cell membrane protein 4
      • TIM-4
      • Tim4
      • TIMD 4
      • TIMD-4
      • Timd4
      • TIMD4_HUMAN
      see all

    • Function

      Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

    • Sequence similarities

      Belongs to the immunoglobulin superfamily. TIM family.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Domain

      Recognizes phosphatidyl serine via its immunoglobulin domain.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab214993? Please let us know so that we can cite the reference in this datasheet.

ab214993 has not yet been referenced specifically in any publications.

Preparation and Storage

  • SMUCKLER
  • Spleen, mucin-containing, knockout of lymphotoxin protein
  • T cell immunoglobulin and mucin domain containing protein 4

Images

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