Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant mouse TIM 4 protein (Fc Chimera) (ab215014)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant mouse TIM 4 protein (Fc Chimera)
    See all TIM 4 proteins and peptides

  • Biological activity

    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated Human T cells.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    Q6U7R4

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      AASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRT DGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFN DVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLP TTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNH SQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKS HQINSRQT

    • Predicted molecular weight

      85 kDa including tags

    • Amino acids

      22 to 279

    • Additional sequence information

      Extracellular domain fused to the N terminus of the Fc region of mouse IgG2a. (NP_848874.3)

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab215014 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

        Functional Studies

      • Form

        Lyophilized
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

        Constituent: 100% PBS

        Lyophilized from 0.2 µm filtered solution.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

      General Info

      • Alternative names

        • SMUCKLER
        • Spleen, mucin-containing, knockout of lymphotoxin protein
        • T cell immunoglobulin and mucin domain containing protein 4
        • T-cell immunoglobulin and mucin domain containing 4
        • T-cell immunoglobulin and mucin domain containing molecule
        • T-cell immunoglobulin and mucin domain-containing protein 4
        • T-cell immunoglobulin and mucin domains-containing protein 4
        • T-cell membrane protein 4
        • TIM-4
        • Tim4
        • TIMD 4
        • TIMD-4
        • Timd4
        • TIMD4_HUMAN
        see all

      • Function

        Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

      • Sequence similarities

        Belongs to the immunoglobulin superfamily. TIM family.
        Contains 1 Ig-like V-type (immunoglobulin-like) domain.

      • Domain

        Recognizes phosphatidyl serine via its immunoglobulin domain.

      • Cellular localization

        Membrane.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab215014? Please let us know so that we can cite the reference in this datasheet.

    ab215014 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • SMUCKLER
      • Spleen, mucin-containing, knockout of lymphotoxin protein
      • T cell immunoglobulin and mucin domain containing protein 4
      • T-cell immunoglobulin and mucin domain containing 4
      • T-cell immunoglobulin and mucin domain containing molecule
      • T-cell immunoglobulin and mucin domain-containing protein 4
      • T-cell immunoglobulin and mucin domains-containing protein 4
      • T-cell membrane protein 4
      • TIM-4
      • Tim4
      • TIMD 4
      • TIMD-4
      • Timd4
      • TIMD4_HUMAN
      see all

    • Function

      Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

    • Sequence similarities

      Belongs to the immunoglobulin superfamily. TIM family.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Domain

      Recognizes phosphatidyl serine via its immunoglobulin domain.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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