Recombinant Human Mesothelin protein (Fc Chimera) (ab185268)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Suitable for: SDS-PAGE
Preparation and Storage
-
Alternative names
- CAK 1
- CAK1
- CAK1 antigen
see all -
Function
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. -
Tissue specificity
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). -
Involvement in disease
Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. -
Sequence similarities
Belongs to the mesothelin family. -
Post-translational
modificationsBoth MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. -
Cellular localization
Secreted and Cell membrane. Golgi apparatus. - Information by UniProt
Images
-
SDS-PAGE - Recombinant Human Mesothelin protein (Fc Chimera) (ab185268)
SDS-PAGE analysis of DTT-reduced (lane 1) and non-reduced (lane 2) staining overnight with Coomassie Blue. DTT-reduced Protein migrates as 60-68 kDa and non-reduced protein migrates as 120-130 kDa.
