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Recombinant Human Mesothelin protein (ab153062)

Key features and details

  • Expression system: Wheat germ
  • Tags: GST tag N-Terminus
  • Suitable for: WB, ELISA

Description

  • Product name

    Recombinant Human Mesothelin protein
    See all Mesothelin proteins and peptides

  • Expression system

    Wheat germ

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQAAPLDGV LANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQL RCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDL LPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESA EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGL LPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTA CPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDV LKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEV NKGHEMSPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSS VPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLG GAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLK AEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSVQEALSGTP CLLGPGPVLTVLALLLASTLA

    • Amino acids

      1 to 621

    • Tags

      GST tag N-Terminus

Preparation and Storage

  • Alternative names

    • CAK 1
    • CAK1
    • CAK1 antigen
    • cleaved form
    • Megakaryocyte potentiating factor
    • Mesothelin
    • Mesothelin isoform 1 precursor
    • MPF
    • Msln
    • MSLN_HUMAN
    • Pre pro megakaryocyte potentiating factor
    • Pre-pro-megakaryocyte-potentiating factor
    • SMR
    • SMRP
    • Soluble MPF mesothelin related protein
    see all

  • Function

    Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

  • Tissue specificity

    Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).

  • Involvement in disease

    Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.

  • Sequence similarities

    Belongs to the mesothelin family.

  • Post-translational
    modifications

    Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.

  • Cellular localization

    Secreted and Cell membrane. Golgi apparatus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Mesothelin protein (ab153062)
    SDS-PAGE - Recombinant Human Mesothelin protein (ab153062)
    ab153062 on a 12.5% SDS-PAGE stained with Coomassie Blue.

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