• Product name

  Mesothelin peptide
  See all Mesothelin proteins and peptides

• Animal free

  No

• Nature

  Synthetic

• Alternative names

  • CAK 1
  • CAK1
  • CAK1 antigen

  • cleaved form
  • Megakaryocyte potentiating factor
  • Mesothelin
  • Mesothelin isoform 1 precursor
  • MPF
  • Msln
  • MSLN_HUMAN
  • Pre pro megakaryocyte potentiating factor
  • Pre-pro-megakaryocyte-potentiating factor
  • SMR
  • SMRP
  • Soluble MPF mesothelin related protein

  see all

• Function

  Membrane-anchored forms may play a role in cellular adhesion.
  Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

• Tissue specificity

  Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).

• Involvement in disease

  Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.

• Sequence similarities

  Belongs to the mesothelin family.

• Post-translational
  modifications

  Both MPF and the cleaved form of mesothelin are N-glycosylated.
  Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.

• Cellular localization

  Secreted and Cell membrane. Golgi apparatus.

• Target information above from: UniProt accession Q13421 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt