Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human DR4 protein (ab641)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human DR4 protein
    See all DR4 proteins and peptides

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      SGTGAAAATP SKVWGSSAGR IEPRGGGRGA LPTSMGQHGP SARARAGRAP GPRPAREASP RLRVHKTFKF VVVGVLLQVV PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRSERPGA CNRCTEGVGY TNASQQLFAC LPCTACKSDE EERSPCTTTR NTACQCKPGT FRNDNSAEMC RKCSTGCPRG MVKVKDCTPW SDIECVHKES GNGHN

    • Predicted molecular weight

      23 kDa

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab641 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        Functional Studies

        SDS-PAGE

      • Form

        Lyophilized

      • Additional notes

        The biological activity of this product was determined by its inhibitory effect of IL-8 production in human PBMC by Human sTRAIL/Apo2L. 95% inhibition (100ng/ml of sTRAIL/Apo2L) was reached using a concentration of 100ng/ml of sTRAIL Receptor-1.
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        RECONSTITUTE with 60ul sterile WATER.

      General Info

      • Alternative names

        • Apo2
        • CD261
        • Cytotoxic TRAIL receptor
        • Death receptor 4
        • DR4
        • NF related apoptosis-inducing ligand receptor 1
        • TNF receptor superfamily member 10a
        • TNF-related apoptosis-inducing ligand receptor 1
        • TNFRSF10A
        • TR10A_HUMAN
        • TRAIL receptor 1
        • TRAIL-R1
        • TRAILR 1
        • TRAILR1
        • Tumor necrosis factor receptor superfamily member 10A
        • Tumor necrosis factor receptor superfamily member 10a variant 2
        • Tumor necrosis factor receptor superfamily, member 10a
        see all

      • Function

        Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

      • Tissue specificity

        Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.

      • Sequence similarities

        Contains 1 death domain.
        Contains 3 TNFR-Cys repeats.

      • Cellular localization

        Membrane.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab641? Please let us know so that we can cite the reference in this datasheet.

    ab641 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • Apo2
      • CD261
      • Cytotoxic TRAIL receptor
      • Death receptor 4
      • DR4
      • NF related apoptosis-inducing ligand receptor 1
      • TNF receptor superfamily member 10a
      • TNF-related apoptosis-inducing ligand receptor 1
      • TNFRSF10A
      • TR10A_HUMAN
      • TRAIL receptor 1
      • TRAIL-R1
      • TRAILR 1
      • TRAILR1
      • Tumor necrosis factor receptor superfamily member 10A
      • Tumor necrosis factor receptor superfamily member 10a variant 2
      • Tumor necrosis factor receptor superfamily, member 10a
      see all

    • Function

      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

    • Tissue specificity

      Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.

    • Sequence similarities

      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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