Recombinant Human DR4 protein (ab55762)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE, Functional Studies
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Product name
Recombinant Human DR4 protein
See all DR4 proteins and peptides -
Purity
> 95 % SDS-PAGE.
> 95% by SDS-PAGE and HPLC analyses Endotoxin level: -
Expression system
Escherichia coli -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
-
Species
Human -
Sequence
MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARAR AGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL H DQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQ LFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CR KCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN -
Predicted molecular weight
23 kDa
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Preparation and Storage
-
Alternative names
- Apo2
- CD261
- Cytotoxic TRAIL receptor
see all -
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. -
Tissue specificity
Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. -
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats. -
Cellular localization
Membrane. - Information by UniProt
