Recombinant Human DR4 protein (Fc Chimera) (ab220558)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Suitable for: SDS-PAGE
Preparation and Storage
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Alternative names
- Apo2
- CD261
- Cytotoxic TRAIL receptor
see all -
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. -
Tissue specificity
Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. -
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human DR4 protein (Fc Chimera) (ab220558)
SDS-PAGE analysis of reduced ab220558 stained overnight with Coomassie Blue.
The protein migrates as 47-49 kDa under reducing condition (SDS-PAGE) due to glycosylation.
