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EPZ0156666, PRMT5 inhibitor (ab254457)

Key features and details

  • Selective, potent PRMT5 inhibitor
  • CAS Number: 1616391-65-1
  • Purity: > 98%

  • Soluble in DMSO to 50 mM

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    EPZ0156666, PRMT5 inhibitor

  • Description

    Selective, potent PRMT5 inhibitor

  • Alternative names

    • GSK3235025
    • YQ36286

  • Biological description

    Selective, potent (IC50 = 22nM, Ki =5 nM) inhibitor of arginine methyltransferase 5 (PRMT5). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases.

  • Purity

    > 98%

  • CAS Number

    1616391-65-1

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

  • Molecular weight

    383.45

  • Molecular formula

    C20H25N5O3

  • PubChem identifier

    90241673

  • Storage instructions

    Shipped at Room Temperature. Store at -20°C long term. Store under desiccating conditions.

  • Solubility overview

    Soluble in DMSO to 50 mM

  • Handling

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CC2=CC=CC=C21)C[C@H](CNC(=O)C3=CC(=NC=N3)NC4COC4)O

  • Source

    Synthetic

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