KT5720, protein kinase A inhibitor (ab141818)
Key features and details
- Potent, selective protein kinase A inhibitor
- CAS Number: 108068-98-0
- Purity: > 98%
- Soluble in DMSO to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KT5720, protein kinase A inhibitor -
Description
Potent, selective protein kinase A inhibitor -
Biological description
Potent, selective protein kinase A (Ki = 60 nM) inhibitor . Reversibly arrests human skin fibroblasts in the G1 phase. Cell permeable. -
Purity
> 98% -
CAS Number
108068-98-0 -
Chemical structure
Properties
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Chemical name
(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4- i][1,6]benzodiazocine-10-carboxylic acid hexyl ester -
Molecular weight
537.61 -
Molecular formula
C32H31N3O5 -
PubChem identifier
454202 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 1 mg/ml -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - KT5720, protein kinase A inhibitor (ab141818)KT5720 inhibits PKAS phosphorylation via PKA.
NIH/C6 cells were preincubated for 45 min with different concentrations of KT5720 (ab141818) and then stimulated with 10 µM Forskolin (ab120058) for 20 min. Cell proteins were resolved by SDS-PAGE and probed with antiphospho-(Ser/Thr) PKAS (PKA substrate).