Fluticasone propionate, Glucocorticoid agonist (ab141281)
Key features and details
- Potent, selective glucocorticoid agonist
- CAS Number: 80474-14-2
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Fluticasone propionate, Glucocorticoid agonist -
Description
Potent, selective glucocorticoid agonist -
Biological description
Potent, selective glucocorticoid agonist (EC50 = 3.7 nM). Higher affinity for the glucocorticoid receptor compared to beclomethasone (Kd = 0.5 nM). Lipophilic anti-inflammatory agent. Biological effects include eosinophil apoptosis, reduction in mast cell production and inhibition of TNF-α induced endothelial cell adhesion. Active in vivo.
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Purity
> 99% -
CAS Number
80474-14-2 -
Chemical structure
Properties
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Chemical name
(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester -
Molecular weight
500.57 -
Molecular formula
C25H31F3O5S -
PubChem identifier
444036 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(SCF)[C@@]4(OC(=O)CC)[C@H](C)C[C@H]3C2C[C@H](F)C1=CC(=O)C=C[C@]1(C)[C@@]2(F)[C@@H](O)C[C@@]34C -
Source
Synthetic
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Research areas
