Estramustine, Microtubule assembly inhibitor (ab142746)
Key features and details
- Microtubule assembly inhibitor. Antiproliferative and induces DNA strand breaks.
- CAS Number: 2998-57-4
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Estramustine, Microtubule assembly inhibitor -
Description
Microtubule assembly inhibitor. Antiproliferative and induces DNA strand breaks. -
Biological description
Microtubule assembly inhibitor. Inhibits endothelial cell proliferation (IC50 = 4.5 μM) and down-regulates prostate-specific antigen expression (IC50 = 10.97 μM). Alkylating and antitumor agent. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
2998-57-4 -
Chemical structure
Properties
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Chemical name
[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl]N,N-bis(2-chloroethyl)carbamate -
Molecular weight
440.40 -
Molecular formula
C23H31Cl2NO3 -
PubChem identifier
259331 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl -
Source
Synthetic
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Research areas
