Erlotinib hydrochloride, EGFR tyrosine kinase inhibitor (ab141930)
Key features and details
- Potent EGFR tyrosine kinase inhibitor
- CAS Number: 183319-69-9
- Purity: > 98%
- Soluble in DMSO to 25 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Erlotinib hydrochloride, EGFR tyrosine kinase inhibitor -
Description
Potent EGFR tyrosine kinase inhibitor -
Alternative names
- CP-358774
- Erlotinib HCl
- NSC718781
see all -
Biological description
Potent EGFR tyrosine kinase inhibitor (IC50 = 2 nM). Decreases EGFR autophosphorylation in tumor cells. Potent inhibitor of mutant JAK2-V617F. Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) and ErbB-4 kinase (Ki = 1.5 μM). Clinically effective agent for non-small cell lung cancer (NSCLC).
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Purity
> 98% -
CAS Number
183319-69-9 -
Chemical structure
Properties
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Chemical name
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride -
Molecular weight
429.90 -
Molecular formula
C22H23N3O4.HCl -
PubChem identifier
176871 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl -
Source
Synthetic
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Research areas
