Borrelidin, threonyl-tRNA synthetase inhibitor (ab144212)
Key features and details
- Potent antiangiogenic agent. Selective threonyl-tRNA synthetase inhibitor.
- CAS Number: 7184-60-3
- Purity: > 98%
- Form / State: Solid
- Source: Streptomyces sp.
Overview
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Product name
Borrelidin, threonyl-tRNA synthetase inhibitor -
Description
Potent antiangiogenic agent. Selective threonyl-tRNA synthetase inhibitor. -
Biological description
Potent antiangiogenic agent (IC50 = 0.8 nM, rat aorta). Selective threonyl-tRNA synthetase inhibitor. Antibiotic agent. CDK inhibitor. Induces apoptosis in capillary tube-forming endothelial cells. Disrupts capillary tubes and inhibits their formation. Shows antiviral and antifungal effects. Shows antiangiogenic effects in vivo. -
Purity
> 98% -
CAS Number
7184-60-3 -
Chemical structure
Properties
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Chemical name
(1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid -
Molecular weight
489.64 -
Molecular formula
C28H43NO6 -
PubChem identifier
6436801 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C -
Source
Streptomyces sp.
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Research areas