Phalloidin, F-actin depolymerization inhibitor (ab143533)
Key features and details
- F-actin depolymerization inhibitor
- CAS Number: 17466-45-4
- Purity: > 95%
- Soluble in DMSO and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Phalloidin, F-actin depolymerization inhibitor -
Description
F-actin depolymerization inhibitor -
Biological description
F-actin depolymerization inhibitor. Competitively binds to actin filaments (Ki = 22 nM) with higher affinity than actin monomers. Increases the rate of polymerization by stabilizing nuclei and polymers as they are formed. Shows hepatoselectivity in vivo. -
Purity
> 95% -
CAS Number
17466-45-4 -
Chemical structure
Properties
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Chemical name
Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3,6)-sulfide -
Molecular weight
788.87 -
Molecular formula
C35H48N8O11S -
PubChem identifier
4752 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(=O)NC2CC3=C(NC4=CC=CC=C34)SCC(C(=O)N5CC(CC5C(=O)N1)O)NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC(C)(CO)O)C)C(C)O -
Source
Synthetic
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Research areas
