10Z-Hymenialdisine, pan kinase inhibitor (ab144275)
Key features and details
- Potent pan kinase inhibitor
- CAS Number: 82005-12-7
- Purity: > 97%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Axinella carteri
Overview
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Product name
10Z-Hymenialdisine, pan kinase inhibitor -
Description
Potent pan kinase inhibitor -
Biological description
Potent pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively). Inhibits NF-κB and IL-8 production (IC50 values are 1-2 and 0.34-0.48 μM respectively, U937 cells). Inhibits MARK2. -
Purity
> 97% -
CAS Number
82005-12-7 -
Chemical structure
Properties
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Chemical name
(4Z)-4-(2-Amino-4-oxo-1H-imidazol-5-ylidene)-2-bromo-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one -
Molecular weight
324.13 -
Molecular formula
C11H10BrN5O2 -
PubChem identifier
3035462 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C\1CNC(=O)C2=C(/C1=C\3/C(=O)N=C(N3)N)C=C(N2)Br -
Source
Axinella carteri
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Research areas