8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor. (ab120442)
Key features and details
- Selective A2A receptor antagonist. MAO-B inhibitor.
- CAS Number: 147700-11-6
- Purity: > 98%
- Soluble in DMSO to 25 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor. -
Description
Selective A2A receptor antagonist. MAO-B inhibitor. -
Biological description
Selective A2A receptor antagonist and MAO-B (monoamine oxidase B) inhibitor (Ki values are 54 and 100 nM, respectively). Affords strong neuroprotection against 6-OHDA-induced neurotoxicity in vitro and is neuroprotective in Parkinson's disease models.
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Purity
> 98% -
CAS Number
147700-11-6 -
Chemical structure
Properties
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Chemical name
(E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione -
Molecular weight
330.77 -
Molecular formula
C16H15ClN4O2 -
PubChem identifier
5353365 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1cccc(c1)/C=C/c3nc2c(C(=O)N(C)C(=O)N2C)n3C -
Source
Synthetic
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Research areas
