Wedelolactone, IkappaB kinase inhibitor (ab144861)
Key features and details
- Selective and irreversible IκB kinase inhibitor
- CAS Number: 524-12-9
- Purity: > 98%
- Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Eclipta prostrasta L.
Overview
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Product name
Wedelolactone, IkappaB kinase inhibitor -
Description
Selective and irreversible IκB kinase inhibitor -
Biological description
Selective and irreversible IκB kinase inhibitor. Inhibits osteoclastogenesis. Suppresses LPS-induced caspase 11 expression (IC50=35 µM). Shows hepatoprotective effects in vivo. -
Purity
> 98% -
CAS Number
524-12-9 -
Chemical structure
Properties
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Chemical name
1,8,9-Trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one -
Molecular weight
314.25 -
Molecular formula
C16H10O7 -
PubChem identifier
5281813 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O -
Source
Eclipta prostrasta L.
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Research areas
