Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor (ab142199)
Key features and details
- Cell-permeable, potent, selective VEGFR tyrosine kinase inhibitor
- CAS Number: 212141-51-0
- Purity: > 98%
- Soluble in DMSO to 50 mM (with warming) and in ethanol to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor -
Description
Cell-permeable, potent, selective VEGFR tyrosine kinase inhibitor -
Alternative names
- 1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate
- CGP 79787
- PTK/ZK
see all -
Biological description
Cell-permeable, potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1) and VEGFR-2 (FLK-1/KDR) (IC50 values are 77 nM and 37 nM respectively). Weaker inhibitor of other tyrosine kinases including PDGFR-β, c-KIT, VEGFR-3 (FLT-4) and c-FMS (IC50 values are 580 nM, 730 nM, 660 nM and 1.4 μM respectively). Inactive against EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 μM). Induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model.
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Purity
> 98% -
CAS Number
212141-51-0 -
Chemical structure
Properties
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Chemical name
N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride -
Molecular weight
419.73 -
Molecular formula
C20H15ClN42.HCl -
PubChem identifier
22386467 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM (with warming) and in ethanol to 10 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl -
Source
Synthetic
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Research areas
