Torin 1, mTOR inhibitor (ab218606)
Key features and details
- Potent, selective mTOR inhibitor
- CAS Number: 1222998-36-8
- Purity: > 98%
- Soluble in DMSO to 3 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Torin 1, mTOR inhibitor -
Description
Potent, selective mTOR inhibitor -
Alternative names
- -(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one
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Biological description
Potent, selective, ATP-competitive mTOR inhibitor that directly inhibits both mTORC1 and mTORC2 complexes, with IC50 values between 2 and 10 nM in in vitro kinase assays. Displays 1000-fold selectivity for mTOR over PI3K, 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34, and exhibits 100-fold binding selectivity relative to 450 other protein kinases. Impairs cell growth and proliferation.
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Purity
> 98% -
CAS Number
1222998-36-8 -
Chemical structure
Properties
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Chemical name
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one -
Molecular weight
607.62 -
Molecular formula
C35H28F3N5O2 -
PubChem identifier
49836027 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 3 mM -
SMILES
CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F -
Source
Synthetic
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Research areas
