SLIGKV-NH2, Protease-activated receptor 2 (PAR2) agonist (ab141809)
Key features and details
- Protease-activated receptor 2 (PAR2) agonist
- CAS Number: 190383-13-2
- Purity: > 98%
- Soluble in water to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SLIGKV-NH2, Protease-activated receptor 2 (PAR2) agonist -
Description
Protease-activated receptor 2 (PAR2) agonist -
Biological description
Protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM and IC50 = 10.4 μM). Tethered ligand of PAR2. Proteolysis of this extracellular domain results in self-activation of this G protein-coupled receptor. Involved in cellular homeostasis and pathology. -
Purity
> 98% -
CAS Number
190383-13-2 -
Chemical structure
Properties
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Molecular weight
614.78 -
Molecular formula
C28H54N8O7 -
Sequence
SLIGKV (Modifications: C-terminal amide) -
PubChem identifier
10483914 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N -
Source
Synthetic
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Research areas
Images
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Functional Studies - SLIGKV-NH2, Protease-activated receptor 2 (PAR2) agonist (ab141809)SLIGKV-NH2 induces MAPK activation in MDA-231 cells via PAR2 activation.
MDA-231 cells were stimulated with 10, 50 and 250 µM SLIGKV-NH2 (ab141809) for 15 min. Cell proteins were resolved by SDS-PAGE and probed with anti-phospho-ERK1/2.