SB 590885, B-Raf kinase inhibitor (ab145185)
Key features and details
- Potent and selective B-Raf kinase inhibitor
- CAS Number: 405554-55-4
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 590885, B-Raf kinase inhibitor -
Description
Potent and selective B-Raf kinase inhibitor -
Biological description
Potent and selective B-Raf kinase inhibitor (Ki = 0.16 nM). Inhibits anchorage-independent cancer cell growth. Inhibits ERK phosphorylation, Shows antiproliferative effects. Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
405554-55-4 -
Chemical structure
Properties
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Chemical name
5-[2-[4-(2-Dimethylaminoethoxy)phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime -
Molecular weight
453.54 -
Molecular formula
C27H27N5O2 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCOc1ccc(cc1)c2nc(c(n2)c3ccc4C(=N\O)/CCc4c3)c5ccncc5 -
Source
Synthetic
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Research areas
