HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor (ab145524)
Key features and details
- Selective, ATP-competitive, reversible Rho-kinase inhibitor
- CAS Number: 155558-32-0
- Purity: > 99%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor -
Description
Selective, ATP-competitive, reversible Rho-kinase inhibitor -
Alternative names
- Hydroxyfasudil
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Biological description
Selective, ATP-competitive, reversible Rho-kinase inhibitor (IC50 values are 0.6 and 0.8 μM for Rock-1 and Rock-2, respectively). Cell-permeable active Fasudil (ab120306) metabolite. Inhibits neutrophil migration and shows potent vasodilatory effects in vivo.
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Purity
> 99% -
CAS Number
155558-32-0 -
Chemical structure
Properties
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Chemical name
5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone hydrochloride -
Molecular weight
343.83 -
Molecular formula
C14H17N3O3S.HCl -
PubChem identifier
11371328 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl -
Source
Synthetic
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Research areas
