NS-1643, HERG (Kv11.1) channel activator (ab141825)
Key features and details
- HERG (Kv11.1) channel activator
- CAS Number: 448895-37-2
- Purity: > 95%
- Soluble in ethanol to 100 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NS-1643, HERG (Kv11.1) channel activator -
Description
HERG (Kv11.1) channel activator -
Biological description
HERG (Kv11.1) channel activator (EC50 = 10.5 μM). Increases erg2 (Kv11.2) currents. Displays antiarrhythmic activity in vitro. -
Purity
> 95% -
CAS Number
448895-37-2 -
Chemical structure
Properties
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Chemical name
1,3-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea -
Molecular weight
380.20 -
Molecular formula
C15H10F6N2O3 -
PubChem identifier
10177784 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - NS-1643, HERG (Kv11.1) channel activator (ab141825)NS-1643 enhances KV11.1 (hERG) currents in Xenopus oocytes.
A. Time course of current amplitude at -40 mV (see B for the voltage stimulating protocol) before, during application of 10 and 30 µM NS-1643 (ab141825) (indicated by bars) and upon wash, demonstrating the current amplitude enhancement. B. Superimposed example traces of KV11.1 channel current responses, before and during application of 10 and 30 µM NS-1643. Currents were elicited by 500 ms voltage step from -100mV to -10 mV followed by a 200 ms step to -40 mV (demonstrated on top) , applied every 10 sec.
