SB 216763, GSK3 inhibitor (ab120202)
Key features and details
- Potent selective GSK3 inhibitor
- CAS Number: 280744-09-4
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 216763, GSK3 inhibitor -
Description
Potent selective GSK3 inhibitor -
Biological description
Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
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Purity
> 98% -
CAS Number
280744-09-4 -
Chemical structure
Properties
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Chemical name
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione -
Molecular weight
371.22 -
Molecular formula
C19H12Cl2N2O2 -
PubChem identifier
176158 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(c(Cl)c1)C=4C(=O)NC(=O)C=4c3cn(C)c2ccccc23 -
Source
Synthetic
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Research areas
