RG-7112, MDM2 inhibitor (ab235500)
Key features and details
- Potent, orally bioavailable MDM2 inhibitor
- CAS Number: 939981-39-2
- Purity: > 98%
DMSO 100 mg/mL (138 mM)
Ethanol 100 mg/mL (138 mM)
Insoluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
RG-7112, MDM2 inhibitor -
Description
Potent, orally bioavailable MDM2 inhibitor -
Alternative names
- RO5045337
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Biological description
Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. Binds MDM2 with KD = 10.7 nM. Blocks the p53- MDM2 interaction with an IC50 of 18 nM in HTRF assays.
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Purity
> 98% -
CAS Number
939981-39-2 -
Chemical structure
Properties
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Chemical name
((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone
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Molecular weight
727.78 -
Molecular formula
C38H48Cl2N4O4S -
PubChem identifier
57406853 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions. -
Solubility overview
DMSO 100 mg/mL (138 mM)
Ethanol 100 mg/mL (138 mM)
Insoluble in water
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl -
Source
Synthetic
