RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT) (ab141013)
Key features and details
- Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT)
- CAS Number: 48208-26-0
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT) -
Description
Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT) -
Biological description
Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
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Purity
> 99% -
CAS Number
48208-26-0 -
Chemical structure
Properties
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Chemical name
N-Phthalyl-L-tryptophan -
Molecular weight
334.33 -
Molecular formula
C19H14N2O4 -
PubChem identifier
702558 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)[C@H](Cc2cnc1ccccc12)N4C(=O)c3ccccc3C4=O -
Source
Synthetic
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Research areas
