Bisdemethoxycurcumin, Apoptotic curcuminoid (ab120976)
Key features and details
- Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid
- CAS Number: 33171-05-0
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bisdemethoxycurcumin, Apoptotic curcuminoid -
Description
Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid -
Alternative names
- BDMC
- Bisdesmethoxycurcumin
- Curcumin III
- Didemethoxycurcumin
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Biological description
Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
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Purity
> 98% -
CAS Number
33171-05-0 -
Chemical structure
Images
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Functional Studies - Bisdemethoxycurcumin, Apoptotic curcuminoid (ab120976)ab18210 staining Bcl2 in HeLa cells treated with bisdemethoxycurcumin (ab120976), by ICC/IF. Decrease of Bcl2 expression correlates with increased concentration of bisdemethoxycurcumin, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120976 (bisdemethoxycurcumin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.