Recombinant mouse Thrombopoietin protein (ab170079)
Key features and details
- Expression system: Insect cells
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Preparation and Storage
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Alternative names
- C mpl ligand
- C-mpl ligand
- Megakaryocyte colony stimulating factor
see all -
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. -
Involvement in disease
Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. -
Sequence similarities
Belongs to the EPO/TPO family. -
Domain
Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant mouse Thrombopoietin protein (ab170079)SDS-PAGE analysis of ab170079.
Lane 1: 3µg ab170079 Reduced
Lane 2: 3µg ab170079 Non-reduced
Lane 3: Molecular weight markers -
Functional Studies - Recombinant mouse Thrombopoietin protein (ab170079)Proliferation of Human TF-1 erythroleukemia cells by ab170079.
