Recombinant mouse IL-1 alpha protein (Active) (ab256050)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Preparation and Storage
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Alternative names
- BAF
- FAF
- Hematopoietin 1
see all -
Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
Sequence similarities
Belongs to the IL-1 family. -
Domain
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
Cellular localization
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
Images
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Functional Studies - Recombinant mouse IL-1 alpha protein (Active) (ab256050)
D10.G4.1 proliferation. ≤10 pg/mL; ≥ 1.0 x 108 units/mg.
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SDS-PAGE - Recombinant mouse IL-1 alpha protein (Active) (ab256050)SDS-PAGE analysis of ab256050 (1μg) under non-reducing (Lane 1) and reducong (Lane 2) conditions.
4-20% Tris-Glycine gel. Coomassie Blue staining.
