• Product name

  Recombinant human BTC protein
  See all BTC proteins and peptides

• Biological activity

  The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

• Purity

  > 95 % SDS-PAGE.
  Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  

• Expression system

  Escherichia coli

• Protein length

  Protein fragment

• Animal free

  No

• Nature

  Recombinant

• • Species

    Human

  • Sequence

    DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

• Alternative names

  • Betacellulin
  • Betacellulin precursor
  • BTC

  • BTC_HUMAN
  • OTTHUMP00000160600
  • OTTHUMP00000219057
  • Probetacellulin

  see all

• Function

  Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors.

• Tissue specificity

  Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

• Sequence similarities

  Contains 1 EGF-like domain.

• Cellular localization

  Cell membrane and Secreted > extracellular space.

• Target information above from: UniProt accession P35070 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt