Recombinant Cynomolgus monkey PD1 protein (Fc Chimera Active) (ab180060)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Suitable for: SDS-PAGE
Preparation and Storage
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Alternative names
- CD279
- CD279 antigen
- hPD 1
see all -
Function
Possible cell death inducer, in association with other factors. -
Involvement in disease
Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Developmental stage
Induced at programmed cell death. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Cynomolgus monkey PD1 protein (Fc Chimera Active) (ab180060)
SDS-PAGE analysis of ab180060 in DTT-reduced (lane 1) and non-reduced (lane 2) conditions. Gel stained overnight with Coomassie Blue. As a result of different glycosylation, DTT-reduced protein migrates as 55-66 kDa and non-reduced protein migrates as 110-140 kDa.
