PRT 4165, Bmi1/Ring1A inhibitor (ab146003)
Key features and details
- Bmi1/Ring1A inhibitor
- CAS Number: 31083-55-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in 1 eq. HCl to 5 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PRT 4165, Bmi1/Ring1A inhibitor -
Description
Bmi1/Ring1A inhibitor -
Biological description
Bmi1/Ring1A inhibitor (IC50 = 3.9 μM). Prevents ubiquitination and drug-induced degradation of topoisomerase. Blocks PRC1-mediated histone H2A ubiquitination in vivo. -
Purity
> 98% -
CAS Number
31083-55-3 -
Chemical structure
Properties
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Chemical name
2-(Pyridin-3-ylmethylidene)indene-1,3-dione -
Molecular weight
235.24 -
Molecular formula
C15H9NO2 -
PubChem identifier
207893 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in 1 eq. HCl to 5 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O -
Source
Synthetic
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Research areas
