NS 1619, KCa1.1 channel activator (ab141824)
Key features and details
- Potent and selective KCa1.1 channel activator
- CAS Number: 153587-01-0
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NS 1619, KCa1.1 channel activator -
Description
Potent and selective KCa1.1 channel activator -
Biological description
Potent and selective KCa1.1 channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).
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Purity
> 98% -
CAS Number
153587-01-0 -
Chemical structure
Properties
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Chemical name
3-[2-Hydroxy-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1H-benzimidazol-2-one -
Molecular weight
362.23 -
Molecular formula
C15H8F6N2O2 -
PubChem identifier
4552 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - NS 1619, KCa1.1 channel activator (ab141824)NS-1619 blocks KCa1.1 currents in Xenopus oocytes.
A. Families of KCa1.1 channel current responses to increasing voltage step stimulation (from -50 mV to + 50 mV), before (left) and during (right) application of 100 µM NS-1619 (ab141824). Currents were elicited by 100 ms voltage step from -100mV applied every 10 sec. B. Time course of current amplitude at 0 mV before, during application of 100 µM NS-1619 (green) and upon wash, demonstrating the current amplitude enhancement. C. Voltage dependence of KCa1.1 channel activity enhancement.
