Mdivi-1, Drp1 inhibitor (ab144589)
Key features and details
- Selective, cell-permeable mitochondrial division Drp1 inhibitor
- CAS Number: 338967-87-6
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mdivi-1, Drp1 inhibitor -
Description
Selective, cell-permeable mitochondrial division Drp1 inhibitor -
Biological description
Selective, cell-permeable mitochondrial division Drp1 inhibitor (IC50 = 10 μM). Inhibits mitochondrial outer membrane permeabilization to prevent apoptosis in vitro. Anti-stroke and neuroprotective agent. Active in vivo and in vitro. -
Purity
> 98% -
CAS Number
338967-87-6 -
Chemical structure
Properties
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Chemical name
3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone -
Molecular weight
353.23 -
Molecular formula
C15H10Cl2N2O2S -
PubChem identifier
3825829 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl -
Source
Synthetic
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Research areas