Linopirdine (DuP-996), M-type K+ current blocker (ab145564)
Key features and details
- M-type K+ current blocker
- CAS Number: 105431-72-9
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Linopirdine (DuP-996), M-type K+ current blocker -
Description
M-type K+ current blocker -
Alternative names
- DuP-996
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Biological description
M-type K+ current blocker (IC50 = 2.4 μM). Neurotransmitter release enhancer. Increases brain acetylcholine release. TRPV1 agonist. Shows cognitive enhancing effects in vivo. Water soluble derivative (ab145548) also available. -
Purity
> 98% -
CAS Number
105431-72-9 -
Chemical structure
Properties
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Chemical name
1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one -
Molecular weight
391.46 -
Molecular formula
C26H21N3O -
PubChem identifier
3932 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5 -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Inhibitors
- Biochemicals
- Pharmacology
- Receptors & Transporters
- GABA
- GABAA
- Benzodiazepine Site
- Antagonists / inverse agonists
