Icaritin, Antiproliferative agent (ab143645)
Key features and details
- Antiproliferative agent
- CAS Number: 118525-40-9
- Purity: > 98%
- Soluble in DMSO to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Icaritin, Antiproliferative agent -
Description
Antiproliferative agent -
Biological description
Antiproliferative agent (IC50 values are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively). Inhibits H/R-induced PTK activation. Induces G(2)/M cell cycle arrest and mitochondrial transmembrane potential drop. Modulates MAPK/ERK/JNK and JAK2/STAT3 /AKT signaling. Inhibits PPAR-g. Modulates differentiation. Inhibits cytochrome P450 in vivo. Orally active. -
Purity
> 98% -
CAS Number
118525-40-9 -
Chemical structure
Properties
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Chemical name
3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one -
Molecular weight
368.38 -
Molecular formula
C21H20O6 -
PubChem identifier
5318980 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)O)C3=CC=C(C=C3)OC)O)O)C -
Source
Synthetic
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Research areas
