Carbamazepine, Neuronal voltage-gated Na+ channel blocker (ab141785)
Key features and details
- Neuronal voltage-gated Na+ channel blocker
- CAS Number: 289-46-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Carbamazepine, Neuronal voltage-gated Na+ channel blocker -
Description
Neuronal voltage-gated Na+ channel blocker -
Biological description
Neuronal voltage-gated Na+ channel blocker. Shows anticonvulsant effects in vivo. Attenuates neuropathic pain behaviours. Potent GABAA current potentiator (EC50 = 25 nM). Orally and centrally active. -
Purity
> 98% -
CAS Number
289-46-4 -
Chemical structure
Properties
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Chemical name
Benzo[b][1]benzazepine-11-carboxamide -
Molecular weight
236.30 -
Molecular formula
C15H12N2O -
PubChem identifier
2554 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N -
Source
Synthetic
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Research areas
Images
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Functional Studies - Carbamazepine, Neuronal voltage-gated Na+ channel blocker (ab141785)Carbamazepine inhibits Nav1.2 channels currents in Xenopusoocytes.
A. Time course of NaV1.2 channel reversible inhibition by 100 µM and 1 mM Carbamazepine (ab141785). Currents were elicited by a voltage step to -20 mV (100 ms) every 10 seconds from a holding potential of -100 mV.
B. Example traces of current response to voltage step application before and during 1 mM Carbamazepine application.