Human IL-17RB Antibody Pair - BSA and Azide free (ab256749)
Key features and details
- Unconjugated capture and detector antibodies
- Adaptable to any antibody pair-based assay format
- Antibody concentration ~ 1 mg/ml
- BSA and azide free buffer - ready for conjugation
- Reacts with: Human
Overview
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Product name
Human IL-17RB Antibody Pair - BSA and Azide free
See all IL-17RB kits -
Assay type
ELISA set -
Range
137.5 pg/ml - 8800 pg/ml -
Species reactivity
Reacts with: Human -
Product overview
The Antibody Pair can be used to quantify Human IL-17RB. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results.
For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab254518), which uses the same antibodies. However, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.
Download SDS here.
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Tested applications
Suitable for: Sandwich ELISAmore details -
Platform
Reagents
Properties
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Storage instructions
Store at +4°C. Please refer to protocols. -
Carrier free
Yes -
Components 10 x 96 tests Human IL-17RB Capture Antibody (unconjugated) 1 x 100µg Human IL-17RB Detector Antibody (unconjugated) 1 x 100µg -
Research areas
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Relevance
Recently, a number of cytokines belonging to the interleukin IL-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E have been independently isolated and have been designated as EV127 (in mouse) and IL-17RH1 (in human), respectively. IL-17E induces activation of NFkB pathway and like IL-17 also induces production of IL-8. IL-17RH1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain. -
Cellular localization
Type I membrane protein (isoform 1). Secreted (isoform 2). -
Alternative names
- CRL 4
- CRL4
- Cytokine receptor CRL4
see all -
Database links
- Entrez Gene: 55540 Human
- Omim: 605458 Human
- SwissProt: Q9NRM6 Human
- Unigene: 5470 Human
Images
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Sandwich ELISA - Human IL-17RB Antibody Pair - BSA and Azide free (ab256749)To learn more about the advantages of recombinant antibodies see here.
