Astana Biomed Group, an authorized Abcam distributor in Central Asia

Human CNTFR knockout HEK293T cell pellet (ab279170)

Overview

  • Product name

    Human CNTFR knockout HEK293T cell pellet
    See all CNTFR kits

  • Product overview

    Abcam’s knockout cell pellets give you access to native proteins, without the need to culture cells. Our knockout cell pellets are prepared from our single-gene knockout cell lines and provide an additional offering to our cell lysates.

    Cells are snap-frozen to provide high quality pellets that are suitable for extraction with alternative lysis buffers or for preparation of lysates from subcellular fractions. Our knockout cell pellets are suitable for a variety of applications, including PCR, gene expression profiling and DNA library preparation.

  • Parental Cell Line

    HEK293T

  • Organism

    Human

  • Mutation description

    Knockout achieved by using CRISPR/Cas9, 7 bp deletion in exon6.

  • Passage number

  • Knockout validation

    Sanger Sequencing

  • Notes

    Pellet size: 5 million cells/vial.

    This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.

Properties

Target

  • Function

    Binds to CNTF. The alpha subunit provides the receptor specificity.

  • Tissue specificity

    Nervous system and skeletal muscle.

  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

  • Alternative names

    • Ciliary neurotrophic factor receptor
    • Ciliary neurotrophic factor receptor alpha
    • Ciliary neurotrophic factor receptor subunit alpha
    • CNTF Receptor alpha
    • CNTF receptor subunit alpha
    • CNTFR
    • CNTFR Alpha
    • CNTFR-alpha
    • CNTFR_HUMAN
    see all

Properties

Images

  • Sanger Sequencing - Human CNTFR knockout HEK293T cell pellet (ab279170)
    Sanger Sequencing - Human CNTFR knockout HEK293T cell pellet (ab279170)
    Homozygous: 7 bp deletion in exon6

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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