Human Apolipoprotein B peptide (ab50068)
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Product name
Human Apolipoprotein B peptide
See all Apolipoprotein B proteins and peptides -
Animal free
No -
Nature
Synthetic -
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Species
Human
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Preparation and Storage
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Alternative names
- Apo B
- Apo B 100
- Apo B-100
see all -
Function
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. -
Involvement in disease
Hypobetalipoproteinemia, familial, 1
Familial ligand-defective apolipoprotein B-100
Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. -
Sequence similarities
Contains 1 vitellogenin domain. -
Post-translational
modificationsPalmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. -
Cellular localization
Cytoplasm. Secreted. - Information by UniProt